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High-risk groups include older adults, vegans, individuals with pernicious anaemia, those with malabsorption conditions such as Crohn's disease or coeliac disease, people taking metformin or proton pump inhibitors long-term, and those with recent nitrous oxide exposure including recreational use

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Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility Standard 2 year carcinogenicity studies in animals have not been performed to evaluate the carcinogenic potential of insulin degludec