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A large retrospective study involving 282 youths showed that topiramate combined with lifestyle interventions led to a 3.4% reduction in BMI, and a reduction in BMI% of the 95th percentile by 9.3%, after 12 months [41]

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A more recent and much larger multicenter, population-based study published yesterday in JAMA Ophthalmology has revealed an elevated inherent relative risk (incidence rate ratio, 1.32) of NAION for those exposed to semaglutide thats much smaller than the 4.28-fold hazard ratio (HR) found in a study published last summer.1 This was a retrospective study across 14 databases (six administrative claims and eight electronic health records)