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One possibility is that the decrease in 2-AG is due to GLP-1R-mediated stimulation of PI3K, 82 or inhibition of PTEN, 83 which will decrease the levels of plasma membrane PIP 2 , one of the precursors for 2-AG synthesis

The role of GLP-1 as an incretin hormone has made the GLP-1 system an attractive treatment strategy for type-2 diabetes mellitus (T2DM)

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Immunocompatible elastomer with increased resistance to the foreign body response

Your MRC Team is also available to answer any questions you may have before getting started or during your treatment

Meta-analyses suggest potential cognitive protection at a population level (Cukierman-Yaffe et al., 2025)