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Absence of Human Trials : Without published human data, the actual duration of bioavailability and the true half-life range in people remain unknown [2]

While vitamin B12 injections are generally considered safe, there are some contraindications to this form of treatment

Role of Vitamin B in Human Health and the Immune System Vitamin B 1 (thiamine) acts as a coenzyme in the pentose phosphate pathway, which is essential for the production of fatty acids, steroids, nucleic acids, and aromatic amino acid precursors, neurotransmitters, and other bioactive compounds that are necessary for brain function [17]

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Most patients who combine both report improved metabolic outcomes