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By weighing the benefits and risks, patients and doctors can determine if self-administration is the right choice on an individual basis

no large-scale controlled human clinical trials establishing safety or efficacy currently exist

Gonzalez-Rellan MJ et al

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Altered peripheral B lymphocyte homeostasis and functions mediated by IL-27 via activating the mammalian target of rapamycin signaling pathway in patients with rheumatoid arthritis