Add 3mL of BAC water for 10mg/mL and the full titration is in reach: 2mg = 20 units, 4mg = 40, 8mg = 80, and 12mg = 120 units (the 12mg step needs a 1.5mL syringe or a split draw)
( ad ) Mean (SE) change from baseline in fasting free fatty acids, n = 68 for AMG 133 and n = 6 for placebo at Day 1 (A), fasting triglycerides, n = 6 for AMG 133 and n = 6 for placebo at Day 1 (B), fasting total cholesterol, n = 68 for AMG 133 and n = 6 for placebo at Day 1 (C), fasting LDL, n = 6 for AMG 133 and n = 6 for placebo at Day 1 (D) after multiple ascending doses of AMG 133 or placebo
Vascular & Systemic Effects: Research includes potential roles in blood vessel formation, wound healing, and modulation of inflammatory pathways
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Nausea is common with initial use and typically diminishes with subsequent doses [2] [4]
It should be taken first thing in the morning with about 4 ounces of water, on an empty stomach