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Reactive intermediates react mainly with polyunsaturated fatty acids (PUFAs), which leads to lipoperoxyl radicals generation, that further interact with lipids, forming lipid radicals and lipid hydroperoxides

Liraglutide and sema: long-acting GLP-1 analogs in rodent models. Journal of Medicinal Chemistry , 58(18), 73707380

doi: 10.1016/j.heliyon.2023.e21876 [DOI] [PMC free article] [PubMed] [Google Scholar] 75.Samra T, Lin RR, Maderal AD

Drug Interaction Studies Clinical Studies and Model-Informed Approaches: The delay of gastric emptying with semaglutide may influence the absorption of concomitantly administered oral drugs

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In these rare cases, combining medications makes clinical sense, but such decisions require individualized medical evaluation and close monitoring of nutritional status