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To resolve the question of whether chronic metformin therapy is associated with greater dependence upon the incretin axis for glucoregulation in type 2 diabetic human patients, more effective incretin antagonists would need to be developed for human use, and so this question remains unanswered

Slow, gradual dosage titration is also key to helping your body adjust to the slowed GLP1 gut motility

however, the dosage needs to be adjusted in patients with renal insufficiency

Cox proportional hazards models determined that men demonstrated a lower yet nonsignificant hazard ratio of developing uveitis at one-year follow-up (hazard ratio

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