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Neuroinflammation, oxidative stress, ion channel alterations, central sensitization and dysfunction of the descending nociceptive modulatory system are among the suggested pathophysiological mechanisms of this debilitating pain 8

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Even at doses far exceeding the standard 10 mcg/kg range (scaled to human-equivalent doses of roughly 200-800 mcg/day for a 70-kg adult), researchers have not observed pathological angiogenesis, tumorigenic signaling, or behavioral toxicity 1

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