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Your dose, form, and how often you take it will depend on: your age the condition being treated how severe your condition is other medical conditions you have how you react to the first dose Dosage for type 2 diabetes Generic: Glipizide Form: oral immediate-release tablet Strengths: 5 mg, 10 mg Form: oral extended-release tablet Strengths: 2.5 mg, 5 mg, 10 mg Brand: Glucotrol Form: oral immediate-release tablet Strengths: 5 mg, 10 mg Brand: Glucotrol XL Form: oral extended-release tablet Strengths: 2.5 mg, 5 mg, 10 mg Adult dosage (ages 1864 years) Extended-release tablets Starting dosage: 5 mg taken by mouth once per day with breakfast Maximum dosage: 20 mg per day Immediate-release tablets Starting dosage: 5 mg taken by mouth twice per day, every 12 hours or 30 minutes before breakfast and dinner Maximum dosage: 40 mg per day Note: If you take glipizide 20 mg or less and are switching from the immediate-release tablets to the extended-release tablets or vice-versa, your dosage will be the same