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Moreover, the combination of tyndallized biomass and postbiotic supernatant enhanced inhibitory activity, which is consistent with evidence that structural components of inactivated bacteria (e.g., cell wall fragments and metabolites) exert bioactive effects ( In vivo , the use of FMO3-KO mice colonized with humanized microbiota via fecal transplant provided a physiologically relevant model for human TMA metabolism
Up-regulated GCL expression to ensure GSH elevation under conditions of inflammatory and oxidative stimulation seems reasonable, as GCL activity is considered especially important for maintaining GSH levels to provide relevant antioxidant defense
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