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Upon cellular fractionation, mutants exhibited a significant decrease in tGSH and GSH in the cytosolic fraction compared to controls, where most cellular GSH is located (Extended Data Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 33.De Flora S., Izzotti A., DAgostini F., Balansky R.M

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Importantly, alterations in DA synthesis capacity in UHR subjects progress over time and are greater in subjects who transition to psychosis relative to those who do not [67]

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