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DXA scans in a subgroup (7.4% of participants) were used to track changes in fat and lean tissue

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The most methodologically sound approach is staggered introduction: start MOTS-c alone for 1014 days to establish baseline metabolic response, then add 5-Amino-1MQ at starting dose and monitor for synergistic effects over the following 1421 days

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Importantly, gradual titration over 20 weeks greatly reduces the incidence and severity of GI side effects