retatrutide triple hormone receptor agonist obesity mechanism of action Dual and Gut Peptide Agonists on the Horizon for the Treatment Type 2 Diabetes and Obesity. An Overview of Preclinical and Clinical Data Frontiers | Mechanisms of action

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The preclinical data suggests the hypothesis that inhibitory GIPR + neurons act specifically on GLP-1R + neurons that drive nausea and food aversion or avoidance to dampen GLP-1R mediated nausea without reducing efficacy, potentially lifting the ceiling of GLP-1R agonist-induced reductions in body weight

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