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Cornerstone 9 , 2329 (2008)

Prescribers review patient progress at minimum every 46 weeks during dose escalation, adjusting titration speed based on gastrointestinal tolerance and weight loss velocity rather than rigidly following manufacturer protocols designed for FDA-approved branded products

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A randomized controlled trial of 12-weeks duration compared a higher dose of gabapentin (2400mg daily) and oestrogen (Premarin 0.625mg daily) against a placebo