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We treated the cells with TGF-2, or the ALK-5 inhibitor, SD-208, or the c-MET inhibitor, EMD1214063

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They establish a regulatory threshold

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Finally, ceramide can follow four major catabolic pathways: (1) phosphorylated by the ceramide kinase (CERK) to form ceramide-1-phosphate (C1P), (2) incorporated into sphingomyelin-by-sphingomyelin synthase (SMS) activity, (3) or into glucosylceramide by the activation of glucosylceramide synthases (GCS), leading to the generation of complex SLs like cerebrosides, gangliosides, sulfatides and globosides