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Topical concentrations

DHODH Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial enzyme that catalyzes the fourth step in the de novo synthesis of pyrimidine nucleotides and is a key enzyme in pyrimidine synthesis

However, a small fraction of APAP undergoes oxidative metabolism by cytochrome P450 enzymes, predominantly cytochrome P450 2E1 (CYP2E1), to form N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive and toxic intermediate

The catalytic degradation of H 2 O 2 by NPs was further confirmed using a hydrogen peroxide assay kit (Fig

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