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Several mycotoxins contain lactone rings, amide, or ester linkages that can be hydrolyzed by specific enzymes
Mechanistic investigations associate these outcomes with signaling pathways involving vascular endothelial growth factor receptor-2 (VEGFR-2) and downstream Akt-eNOS activation, processes that collectively facilitate efficient muscle tissue remodeling (5)
The system works as follows: regenerative silk fibroin nanofiber hydrogels, carrying the nanorobots, are activated by NIR to actively move deep into the bone metastasis microenvironment, release thrombin to induce local microvascular embolization, and simultaneously use gold nanorods for photothermal therapy