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Fourth, GLP-1R protein is more prevalent in axon terminals than in neuronal cell bodies, and it is possible that endogenous GLP-1 and GLP-1R agonists may bind to GLP-1 receptors in regions beyond those in which GLP-1R mRNA is expressed

10.1016/j.vetimm.2011.10.020 160

Middleton, 2023

If you want a deeper look at the biology behind this class of medication, this explanation of how GLP-1 actually works for weight loss is a useful next read

In the current study, we identified three DE clusters with distinct phenotypes that can potentially be used to identify the course and treatment targets of DE (dopamine and glutamate neurotransmitter system targeted drugs for K1 and K2, and glutamatergic drugs for K2, and antioxidants, especially for K1 and K2)