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doi: 10.4093/dmj.2016.40.4.253, 20

Oral semaglutide (7 and 14 mg) was superior to sitagliptin in reducing body weight from baseline at Week 26 (ETD: 1.6 kg and 2.5 kg, respectively

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The presence of insulin resistance and elevated pro-inflammatory cytokines (e.g., tumor necrosis factor-) induce hepatic GH resistance (64), causing increases in GH and decreases in IGF-I levels ( Table 1 )