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Employing RMSD pocket residues, paired calculations facilitated the identification of the key residues comprising the active site (key pocket), including Tyr-72, Asp-74, Trp-86, Gly-120, Gly-121, Tyr-124, Tyr-133, Glu-202, Ser-203, Trp-286, Phe-295, Phe-297, Tyr-337, Phe-338, Tyr-341, His-447, and Gly-448