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Its synthesis depends on two essential amino acids: lysine and methionine

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Bibcode:1987PNAS...84.2377B

This was evidenced by in vivo studies, which revealed a markedly reduced expression of PGC-1 and its target genes in the striatum and muscle of HD mice ( A number of in vivo studies have demonstrated that mHtt is involved in the process of mitophagy or regulates intermediately important aspects in animal models of HD

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