does semaglutide cause cancer in humans Ozempic and GLP-1 Drugs: Risk of Severe Side Effects Is Semaglutide Linked to Cancer?

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Hou X, Wang Z, Peng M

The lower affinity for GLP-1R reduces dose-limiting gastrointestinal adverse effects like nausea and vomiting, which are frequently linked to high GLP-1R activity

The rate varies based on starting weight, dosage, and concurrent lifestyle modifications

No lab work is required by default, and the company reports that labs are requested in fewer than 1 in 1,000 cases

Its diabetes drug Mounjaro (tirzepatide, a GLP-1/GIP dual agonist) showed superior weight-loss to Wegovy (about 20% average body weight reduction vs ~14% in a head-to-head trial) ( [18] ), and its obesity-specific formulation Zepbound rapidly gained market share (reaching ~$3.6B sales in Q3 2025 ( [19] ))