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While IOP remained unaffected, SPE treatment effectively attenuated oxidative stress and inflammation, as evidenced by reduced levels of 4-HNE, IL-6, and pNF-B

SURPASS-4 confirmed no significant increase in risk of cardiovascular disease with tirzepatide in a high-risk population, and a pre-specified meta-analysis demonstrated a hazard ratio of 0.8 for major adverse cardiovascular events (cardiovascular death, non-fatal stroke or myocardial infarction, or hospitalisation for unstable angina) over 55 weeks

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Skyler, Frank J