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Safety in Hypothyroidism Pharmacology of Semaglutide and Hypothyroidism In patients with primary hypothyroidism, levothyroxine replaces deficient T4 while semaglutide targets the GLP-1 receptor to aid glycemic control and weight loss

Adopting a ketogenic lifestyle after discontinuing these medications offers a sustainable strategy for maintaining weight loss and supporting metabolic health

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Healthcare providers can assess whether symptoms represent normal adjustment to semaglutide or indicate a need for dose modification, temporary discontinuation, or investigation for alternative diagnoses