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Likewise, 527 bp of the upstream and 446 bp of the downstream regions of the GDH3 gene were amplified and fused with the SAT1 fragment to form a disruption cassette (~6 kb) for GDH3 gene deletion (Supplementary Fig

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The receptor exists in two splice variants: the active GHS-R1a, which binds acylated ghrelin, and the truncated GHS-R1b, which is pharmacologically inactive but can modulate the activity of 1a through heterodimerisation

This stability and carrier-free effectiveness distinguish BPC-157 from other growth factor-based therapies that typically require complex delivery systems

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