We know that cholesterol induces the hormone synthesis such as cortisol, the aldosteron, the testosteron and the oestrogens which are the sex hormones may be the increasing in cholesterol in the HCD rats would have contributed to increase the rate of these hormones and induce significantly increasing of body weight in rat fed with HCD (Fidele, Barama, Talla, & Dimo, 2017)
R.GiladiA.Lara-AstiasoD.et al (2016)
And then probably most importantly, if we stop a medication, how do we deal with weight regain
Downregulation of the p53 signaling pathway promotes cellular proliferation and modulates inflammatory responses 71 , while HDAC7 depletion facilitates cell migration, angiogenesis, and extracellular matrix remodeling, collectively contributing to coordinated tissue repair 72
10.1016/S0031-9384(98)00145-0 302 MaC.HongF.YangS
In these situations, I recommend B12 shots as first-line therapy over oral forms