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The safety of vitamin E also must be considered: a recent meta-analysis in the nonkidney-disease population suggested that doses of 400 U/d or more of vitamin E were associated with an increase in all-cause mortality

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However, the dual glucose-dependent insulinotropic polypeptide receptor (GIPR)/GLP-1R agonist, tirzepatide, has demonstrated superior efficacy regarding improvements in HbA 1c and body weight in people with type 2 diabetes

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