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There may be a chance of interactions depending on what form of MSM you take

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Experimental and Clinical Cancer Research CR 37 (1), 63

Intestinal and Cellular Thiamine Uptake Thiamine uptake from the intestines is a function of the solute carrier transporter family member encoded by the SLC19A2 gene

Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress

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