The limitations of the study, as acknowledged by the authors, include the lack of individual patient data and the relatively low percentage of participants with a history of stroke
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Yamamoto K, Okano H, Miyagawa W, Visse R, Shitomi Y, Santamaria S et al (2016) MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1
Therefore, collectively, these studies imply that these antioxidant strategies are not effective in ALS