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PMID: 41851454 ACS Nano Enzyme-Triggered Transcytosis of Dendrimer-Drug Conjugate for Deep Penetration into Pancreatic Tumors

it always depends on the specific research objective and model

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Passive diffusion for CNS drug delivery is highly constrained because of the selective permeability of the BBB, which is maintained by tight junctions, adherens junctions, and the phospholipid bilayer of endothelial cells