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Itaconate is a metabolite synthesized by cis-aconitate decarboxylase and is produced by lipopolysaccharide-activated macrophages through the diversion of cis-aconitate from the tricarboxylic acid cycle

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They contribute to a permissive microenvironment that favors angiogenesis, cell migration, matrix stiffening, and in turn invasive phenotypes [95, 96]

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