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Their enhanced permeability profiles reduce systemic side effects in applications such as antihypertensive and topical antibiotic delivery (Yang M

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These combined actions have led to interest in its relevance for research models involving cardiovascular stress and impaired circulation.(23) Further animal-based investigations have reported protective effects in models of cardiac injury

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From these, we selected for estimation parameters that were not available from literature and that are most directly associated with the dynamics of the GSH and GSSG concentrations ([GSH] and [GSSG], respectively), for which we had available experimental data

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