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It can also conjugate with chemicals and make it water soluble and so you can pee it out

Yasuhara T, Shingo T et al (2004) Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of Parkinsons disease

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The bigger oral semaglutide weight loss data comes from the OASIS trials, which used the 25 mg and 50 mg doses (the higher doses are not currently approved)