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96 In PWS, recurrent psychoses are relatively frequent, especially in patients with UPD, after adolescence

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Simultaneously, JNK-mediated phosphorylation of Bcl-2 disrupts its association with Beclin-1, enhancing both apoptosis and autophagic cell death (79)

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Both diseases are known to reduce quality of life and lead to serious complications, such as cardiovascular events and microangiopathic alterations in eyes, kidneys, and peripheral nerves