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Although these agents improve glucose levels in patients with type 2 diabetes, their weightlowering effects may be as or more clinically meaningful for patients with obesity

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Consistent with DOG box enrichment, all GS-like genes from Clade 3 analysed by in situ hybridisation were highly and specifically expressed in the secretory dorsal gland cells in a range of parasitic stage nematodes (Fig 2A and S3 Fig), while Clade 1 and Clade 2 GS-like genes were expressed in both female and male nematodes, with often preferential expression in the intestine (Fig 2A and S3 Fig

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External factors like UV exposure and oxidative stress further accelerate this process