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Of concern, is the novel finding that chronic exposure to HFSD during adulthood, consistently downregulates PPG mRNA expression (but not GLP-1R)

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J Exp Bot 57:30333042 Navrot N, Collin V, Gualberto J, Gelhaye E, Hirasawa M, Rey P, Knaff DB, Issakidis E, Jacquot JP, Rouhier N (2006) Plant glutathione peroxidases are functional peroxiredoxins distributed in several subcellular compartments and regulated during biotic and abiotic stress

The three GLP-1 medications approved by the FDA to treat obesity include: Liraglutide (Saxenda/Victoza) Semaglutide (Wegovy/Ozempic/Rybelsus) Tirzepatide (Zepbound/Mounjaro) GLP-1 medications can lead to an average weight loss of 10% to 20% over 12-24 months when used alongside healthy diet and exercise changes