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Therapeutic strategies targeting cysteine metabolism in cancer Throughout this review, the trans-sulphuration pathway has been presented as a metabolic pathway that involves the interconversion (and de novo synthesis) of cysteine and homocysteine through the intermediate cystathionine, cysteine being a critical component of glutathione (Fig

Research has demonstrated that increased expression of PD-L1 in tumor cells leads to immunosuppression within the tumor microenvironment, serving as a critical mechanism for tumor evasion by the immune system [79]

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