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1h,i) and sensitized MYC-driven cells to DNA-damaging agents, which was rescued by supplementation of KG (Extended Data Fig

This study elucidates the non-selective activation mechanism by determining cryo-EM structures of Cagri bound to AMY 1 R-G s and CTR-G s complexes

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This study demonstrated that sequestration of NRF2 by progerin, which results in protein mislocalization and the impairment of NRF2-mediated antioxidant response, contributes to progerin-associated nuclear aging defects [115]