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The absorption of a coffee enema is assumed to require a similar amount of time as that for ingested coffee

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doi: 10.1081/CSS-120001104 63 KumarV.YadavA

It arises due to a combination of genetic and lifestyle factors that contribute to defective production of insulin from pancreatic beta cells, and/or resistance to its uptake by insulin receptors located in peripheral and central tissues in the body