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As the glymphatic pathway flushes A towards the perivascular space, which may influence clearance through BBB 1, 15, 28 , the issue of whether GABA and glutamate modulate BBB permeability or act via interactions with receptors for advanced glycation end products (RAGE) or low density receptor-related protein-1 (LRP1) requires further investigation
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Rotate injection sites systematically (abdomen, thighs, upper arms) to reduce local irritation