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N Engl J Med 1995

FIGURE 1 FIGURE 2 CP-induced renal toxicity was originally reported by laboratory animal research in 1971 (Kociba and Sleight, 1971)

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Davies MJ, Aroda VR, Collins BS, Gabbay RA, Green J, Maruthur NM, Rosas SE, Del Prato S, Mathieu C, Mingrone G, et al

This fat-based shell acts as a protective "delivery vehicle." Because the liposome is made of the same material as your cells, it is not recognized as a foreign protein to be digested

This is not a reason to start metformin on its own, but it is a relevant consideration if metformin is already part of the clinical conversation