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Treatment with liraglutide injection 1.2 mg and 1.8 mg as add-on to metformin resulted in a significant mean HbA1c reduction relative to placebo add-on to metformin and resulted in a similar mean HbA1c reduction relative to glimepiride 4 mg add-on to metformin (Table 4)

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The increased inflammatory environment may cause insulin resistance and reduced glucose uptake in insulin-sensitive tissues (muscle and liver), thereby causing glucose intolerance

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