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1,25-dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system

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It plays a key role in maintaining intracellular FA homeostasis by regulating the transcription of FAO-related enzymes in mitochondria and peroxisomes, and modulates cellular FA uptake through regulating the expression of CD36 and CPT1 ( PGC-1 is a key regulator of mitochondrial biogenesis ( + levels, thereby promoting mitochondrial biogenesis and mitophagy

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Known as the master antioxidant for its ability to recycle other antioxidants such as vitamin C, it plays a crucial role in supporting the natural detox process

doi:10.1016/s0022-2836(03)00347-4