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(2) Study design (clinical trial registration number)

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Calculation: First, convert the mouses weight to kilograms: 30g = 0.03 kg

In dogs at 52 weeks of treatment at the NOAEL of 40 mg/kg, which is approximately 3 times the MRHD (400 mg) on a mg/m2 body surface area, the AUC7d values were approximately 59 mcgh/mL in males and 44 mcgh/mL in females

Cell viability was assessed using the Cell Counting Kit-8 (CCK8) assay, measuring metabolic activity as an indicator of cell health