The overall safety of GLP-1 drugs is still being monitored as more patients start long-term use
Data availability Data supporting these findings are included within the article and its supplementary material or from the corresponding author upon request
Mazzeo, L
no therapeutic intervention trials published Cell culture Skeletal muscle myoblasts, cardiomyocytes, endothelial cells, fibroblasts, mesenchymal stem cells Ex vivo tissue preparations Isolated mitochondria, cardiac tissue preparations for respiration studies Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite over 100 published preclinical studies and growing scientific interest, MOTS-c faces substantial translational barriers that limit clinical application and necessitate cautious interpretation of its therapeutic potential
Likewise, loss-of-function mutations in another Ca 2+ -channel Transient receptor potential cation channel, subfamily M, member 2 (TRPM2) are also associated with human bipolar disorder and Trpm2 null mice display manic-like behaviours [29]
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