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Pachymic acid (PA), a triterpenoid compound isolated from Poria cocos , has been shown to ameliorate renal injury in a mouse model of renal I/R, potentially by inhibiting renal ferroptosis through the upregulation of the NRF2/HO-1 axis (90)
Regular alcohol consumption thus creates a dual acetaldehyde burden, impairs gut barrier integrity, suppresses immune function, and provides fermentable substrates for yeast growth
Such interactions could remodel the cells metabolic profile and also have dramatic effects on stress-response pathways involving metabolite quenchers