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tirzepatide lowered HbA 1c by 2.01 to 2.30 percentage points versus 1.86 for semaglutide, meeting non-inferiority and superiority, with greater weight loss as well

418,419,420,421,422,423 It is worth noting, however, that investigations on E/I imbalance have primarily been carried out using animal models, therefore a detailed assessment of the pathophysiology of E/I imbalance contributing to human ASD is warranted

The trade-off is a broader side effect profile caused by non-selective receptor activation

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doi: 10.1007/s10620-008-0598-y

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