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When redox homeostasis is disrupted, excess ROS compromise the integrity of DNA, RNA, and proteins, promoting mutations, chromosomal breaks, and, in extreme cases, cell death (He et al

A tripped indicator means the product was exposed to out-of-range temperatures during transit and the pharmacy should replace it

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While aldafermin development was halted [159161], other FGF-21 analogs are showing favorable results and are moving toward phase 3 trials [162166]

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Dose adjustment is not recommended in patients with mild-severe renal impairment (eGFR = 15-89 mL/min/1.73 m 2 ), but use is not recommended for patients with end-stage renal disease (127)