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2) the gut microbiota might be not only the pharmacological target, but also the main site of metabolism, resulting in a low oral bioavailability

It has been observed that using a needle that is too short may inadvertently lead to subcutaneous administration of the vaccine ( Figure 1 ), resulting in reduced vaccine efficacy, seropositivity, and antibody titers compared to an intramuscular injection (3)

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Nitric Oxide (NO) pathway: It upregulates nitric oxide synthase, leading to vasodilation, improved blood flow, and reduced inflammation at injury sites

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